Kereiti ea Meriana ea Triglycerides ea Medium-Chain (MCT) | Solvent ea Lipophilic & Moriana oa Meriana bakeng sa Molomo/Setlolo/Se ka Enteloang | USP/EP/ChP

Li-Triglyceride tsa Ketane e Mahareng ea Meriana (MCT)

Kakaretso ea Sehlahisoa

Medium-Chain Triglycerides (MCT) ke setlhare se thehiloeng hantle se nang le motsoako oa triglycerides oa li-acid tse mafura tse tletseng, haholo-holo caprylic acid (C8H16O2, octanoic acid) le capric acid (C10H20O2, decanoic acid)Li-triglyceride tsena li fumanoa ho tsoa oli e tsitsitseng e ntšitsoeng karolong e thata, e omisitsoeng ea endosperm ea kokonate (Cocos nucifera L.) kapa ho tsoa endosperm e omisitsoeng ea palema ea oli (Elaeis guineensis Jacq.)Li-acid tse mafura li aroloa ho oli e mafura ebe li kenngoa hape ka glycerol ho hlahisa sehlahisoa sa ho qetela..

Boitsebiso ba Sehlahisoa:

• Lebitso la Khemikhale:Li-Triglyceride tsa Ketane e Mahareng / Caprylic/Capric Triglyceride

• Nomoro ea CAS:73398-61-5 (hape 85409-09-2 kapa 538-24-9)

• Nomoro ea Ngoliso ea CDE:F20220000316

• Ho Latela Melao ea Pharmacopoeia:ChP (CP2020), USP-NF (Li-Triglyceride tsa Methati e Bohareng), EP (Li-Triglyceride, Methati e Bohareng), JP (Triglyceride ea mafura a ketane e mahareng)

• Mantsoe a tšoanang:Oli ea MCT, Caprylic/Capric Triglyceride, Glycerides e tsoakiloeng ka decanoyl le octanoyl, Miglyol® 812 e lekanang, Labrafac™ CC e lekanang

• Ponahalo:Mokelikeli o nang le oli o se nang 'mala ho isa ho o mosehla hanyane, o batlang o se na monko ebile o se na tatso

• Sebaka sa ho Hatsela:Hoo e ka bang 0°C

Likarolo tsa Bohlokoa le Melemo

1. Litšobotsi tse Phahameng tsa Solvent

• Sethapo se setle haholo bakeng sa lithethefatsi tsa lipophilic le li-API tse sa qhibiliheng hantle metsing

• E ntlafatsa ho qhibiliha le ho tsitsisa metsoako ea lipophilic

• E ntlafatsa ho fumaneha ha meriana ea Sehlopha sa II le sa IV (karolelano ea BCS)

2. Ho Monya ka Potlako le Metabolism

• E monyeloa ka ho toba ka har'a potoloho ea mali ea portal ntle le tlhoko ea letsoai la bile kapa li-enzyme tsa pancreatic

• E silafala ka potlako ho fana ka matla a potlakileng

• Ho fana ka API ka potlako ho potoloho ea 'mele, e leng se ka ntlafatsang qalo ea ts'ebetso

3. Profaele e Hlollang ea Botsitso

• Ho hanyetsa ka ho feletseng oksijene (boleng ba iodine ≤1.0)

• Ho ba le tšekamelo e tlase ea khatello ea mocheso le ea oxidative

• E boloka botsitso le nako ea ho boloka meriana e sebelisoa

• E tsitsitse maemong a fapaneng a mocheso oa polokelo (e khothaletsoa ho ≤25°C)

4. Matlotlo a Phahameng a 'Mele

• Ho tsikinyeha:~30 mPa·s ho 20°C (ho teteana ho tlase bakeng sa ho sebetsana habonolo)

• Matla a khoheli a itseng:0.93-0.96 ho 20°C

• Index ea Refractive:1.440-1.452 ho 20°C

• Viscosity e tlase e loketseng mefuta ea tekanyo ea metsi le e tiileng hanyane

5. Ho lumellana ho hotle haholo

• E lumellana le mefuta e mengata ea li-API le metsoako ea meriana

• E ka kenyelletsoa habonolo mefuteng e fapaneng ntle le mathata a ho lumellana

• Monko le tatso tse sa nke lehlakore - li loketse metsoako e nooang moo ho leng bohlokoa ho e utloa.

6. Profaele ea Taolo le Polokeho

• Boemo ba GRAS (Ka Kakaretso bo Tsejoang e le bo Sireletsehileng)

• Ha e na chefo, ha e halefise letlalo le mahlo

• LD50 (toeba, molomo): 29.6 g/kg – e bolokehile haholo

• GMP e entsoe ka taolo e matla ea boleng

• CDE e ngolisitsoe (F20220000316) bakeng sa 'maraka oa Chaena

• E fumaneha ka tšehetso ea taolo bakeng sa lifaele tsa lefats'e ka bophara